Our research focus
Signaling in Bone Biology
The skeleton is a highly dynamic tissue that undergoes continuous remodeling throughout life. Bone remodeling depends on a delicate balance between osteoclastic resorption and osteoblastic new bone formation. Deregulation of these activities unleashes pathological states with a high social impact such as osteoporosis, osteosclerosis and heterotopic bone formation.
Understanding bone cell signaling is critical, due to its importance in cellular fate decisions and because malfunctions in signaling are at the heart of many bone pathologies such as osteoporosis or fibrodisplasia ossificans progressiva (FOP).
Our projects focus on the application of genetics and molecular and cellular biology strategies to investigate bone homeostasis in vivo, with the aim of finding and testing new targets to improve therapeutic outcomes for bone pathologies.
Ventura lab
Latest publications
Ventura F, Williams E, Ikeya M, Bullock AN, Ten Dijke P, Goumans MJ, Sanchez-Duffhues G.
Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva
Biomedicines
Volume: 9 Number: 2 Pages, 213
Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F.
NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression
Redox Biology
Volume: 40 Number: Pages, 101845
Valer, J.A.; Sánchez-de-Diego, C.; Gámez, B.; Mishina, Y.; Rosa J.L.; Ventura, F.
Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification
EMBO Molecular Medicine
Volume: 11 Number: 9 Pages, e10567
CONTACT US
ADDRESS
Dr. Francesc Ventura
University of Barcelona
School of Medicine
Feixa Llarga s/n, 4th Floor
L’Hospitalet del Llob, 08907
Spain
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