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Our research focus

Signaling in Bone Biology

  The skeleton is a highly dynamic tissue that undergoes continuous remodeling throughout life. Bone remodeling depends on a delicate balance between osteoclastic resorption and osteoblastic new bone formation. Deregulation of these activities unleashes pathological states with a high social impact such as osteoporosis, osteosclerosis and heterotopic bone formation.

  Understanding bone cell signaling is critical, due to its importance in cellular fate decisions and because malfunctions in signaling are at the heart of many bone pathologies such as osteoporosis or fibrodisplasia ossificans progressiva (FOP).

    Our projects focus on the application of genetics and molecular and cellular biology strategies to investigate bone homeostasis in vivo, with the aim of finding and testing new targets to improve therapeutic outcomes for bone pathologies.

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Ventura lab

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Latest publications

Ventura F, Williams E, Ikeya M, Bullock AN, Ten Dijke P, Goumans MJ, Sanchez-Duffhues G.
Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

Biomedicines

Volume: 9  Number: 2  Pages, 213                                                             

           

Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F.

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

Redox Biology

Volume: 40  Number:    Pages, 101845 

 

Valer, J.A.; Sánchez-de-Diego, C.; Gámez, B.; Mishina, Y.; Rosa J.L.; Ventura, F.

Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification
EMBO Molecular Medicine

Volume: 11  Number: 9   Pages, e10567 

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CONTACT US

ADDRESS

Dr. Francesc Ventura

University of Barcelona
School of Medicine

Feixa Llarga s/n, 4th Floor
L’Hospitalet del Llob, 08907
Spain

fventura@ub.edu

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